Prolonged Drug Release from Gels, using Catanionic Mixtures

The effective use of catanionic drug-surfactant a combination was shown to be a proficient novel manner of obtaining prolonged drug release from gels. It was basically revealed that several regularly used drug compounds have the ability to form catanionic mixtures along with oppositely charged surfactants. These mixtures exhibited unique phase behaviour, where, among different structures, vesicles and huge worm-like or branched micelles put together. The length of these aggregates brings about a prospective way of prolonging the drug release from gels, as only monomer drugs in equilibrium with larger aggregates were readily capable to diffuse throughout the gel. Once the diffusion coefficient for drug release out of the formulation based on a catanionic mixture was opposed for that obtained to the drug substance and gel alone, the coefficient was some 10 to 100 times smaller.The impact of modifications in the pH and ionic strength for the catanionic aggregates seemed to be investigated…

Contents: Prolonged Drug Release from Gels, using Catanionic Mixtures

1 Introduction
1.1 Gels As Pharmaceutical Dosage Forms
1.1.1 What Is A Gel?
1.1.2 A Dosage Form Of Great Potential?
1.1.3 The Advantages Of Using A Gel
1.2 The Problem
2 Aims Of The Thesis
3 Catanionic Mixtures
3.1 What Is A Catanionic Mixture?
3.2 Catanionic Micelles
3.3 Catanionic Vesicles
3.4 Catanionic Mixtures In A Physiological Environment
4 Experimental Section
4.1 Materials
4.2 Composing The Phase Diagrams
4.3 Preparation Of Gels
4.4 Rheological Measurements
4.5 Drug Release Studies
4.6 Determination Of The Cmc
4.7 The Interaction Parameter
4.8 Statistical Analysis
5 Results And Discussion
5.1 Do Drugs Form Catanionic Aggregates With Oppositely Charged Surfactants?
5.2 Do Catanionic Aggregates Affect The Drug Release From Gels?
5.3 Will The Use Of Catanionic Mixtures Work In A Physiological Environment?
5.4 Can The Oppositely Charged Surfactant Be Changed Into Something Less Toxic?
5.5 Some Discoveries Concerning The Release
Mechanisms…