Stem Cell Factor (SCF) can function as a survival factor, a mitogen or a chemoattractant depending on cell type. Binding of SCF to c-Kit induces dimerization and subsequent autophosphorylation of the receptor. This report represents the intracellular indicate transduction elicited by c-Kit.In the search for alert transduction molecules capturing..
Post natal care – various care options
Around high-income nations, medical center period of stay after having a normal delivery has steadily reduced correspondingly to period of stay in proper care of other patients. A brief stay offers a greater opportunity for autonomy as well as an increased feeling of contribution, however it may involve great issues fulfilling parental guidance as well [...]
Single-molecule Detection in situ
The human body contains a variety of different cell types that share a common genome, but differ in how they use the information encoded therein. Variation in molecular content exists even at the level of individual cells, and to provide deeper insight into complex cellular processes methods that permit analysis of each cell on its [...]
Hormones and fluid balance during pregnancy, labor and post partum
The aim of this thesis was to determine any association between plasma oxytocin and vasopressin concentrations and renal water and sodium excretion during normal pregnancy. In addition to investigate changes in concentrations of estradiol, progesterone, oxytocin, cortisol, and glucose in the blood before and in the nearest hours after delivery and if treatment with oxytocin [...]
Platelet Activation and Inhibition in Connection with Vascular Stents
This thesis describes the Chandler loop, which makes it possible to conduct studies in vitro of molecular and cellular interactions between whole blood and stents. It was possible to monitor activation and inhibition of the cascades systems, leukocytes and platelets by combining different platelet inhibitors and heparin coating of stents… Contents Introduction Chapter 1. THROMBOSIS [...]
Targeting Early Stages of Alzheimer’s Disease in a Transgenic Model
The Arctic mutation causes early-onset Alzheimer’s disease (AD), and makes amyloid-β (Aβ) peptides more prone to form Aβ protofibrils. The aims of this thesis were to investigate the mechanisms of the Arctic mutation in vivo, and to use transgenic models to determine the role of early intermediates of Aβ aggregation, like protofibrils… Contents Introduction Alzheimer’s [...]
Partners’ Attributions and Level of Commitment as Predictors of Constructive and Destructive Behavior in Discussions of Relationship Conflicts
This study investigated whether clinical couples’ levels of commitment to their relationship and their tendencies to make negative attributions about their partner are related to their use of constructive and destructive behavior during couple conflict. Secondary analyses were conducted on assessment data from 52 couples who sought couple therapy at a university-based clinic… Contents Chapter [...]
Outcom After Haemorrhoidopexy
This dissertation is composed of five individual studies of the stapled haemorrhoidopexy operation. The operation was launched to an international audience in 1998 by the Italian surgeon Antonio Longo. In conventional surgery the prolapsed piles are excised from the anodermal part of the prolapse up through the anal canal into the lower rectal mucosa where [...]
Health economic studies on advanced home care
The aim of this thesis was to examine the cost-effectiveness of specific advanced home care and home rehabilitation interventions and to improve economic evaluation methods when applied to advanced home care. This included a comparison of two alternative ways of administering oxygen at home to patients with chronic hypoxaemia… Contents Introduction Terminology related to home [...]
Microbe-induced apoptosis in phagocytic cells and its role in innate immunity
Apoptosis, or programmed cell death, is a controlled process by which aged or damages cells are eliminated in multicellular organisms. Neutrophils, short-lived phagocytes of the innate immune system, are highly equipped effectors that can sense, locate, ingest and kill bacterial pathogens. Inflammatory mediators and the presence of bacterial products at the foci of infection regulate [...]