Turbulence is described by its main characteristics that are irregularity in time and space In hydromechanics, turbulence is referred to as chaotic movement superimposed on the flow of a fluid In the human body, turbulence typically arises in flows through heart valve prostheses and vascular or valvular stenoses. This thesis exploits a magnetic resonance imaging [...]
Multidimensional MRI of Cardiac Motion: Acquisition, Reconstruction and Visualization
Methods for measuring deformation and motion of the human heart in-vivo are crucial in the assessment of cardiac function. Applications ranging from basic physiological research, through early detection of disease to follow-up studies, all benefit from improved methods of measuring the dynamics of the heart. This thesis presents new methods for acquisition, reconstruction and visualization [...]
Phase Contrast MRI Measurements
Title: Simulation of Phase Contrast MRI Measurements from Numerical Flow Data Phase-contrast magnetic resonance imaging (PC-MRI) is a powerful tool for measuring blood flow and has a wide range of cardiovascular applications. Simulation of PC-MRI from numerical flow data would be useful for addressing the data quality of PC-MRI measurements and to study and understand [...]
Processing of the Phonocardiographic Signal: methods for the intelligent stethoscope
Phonocardiographic signals contain bioacoustic information reflecting the operation of the heart. Normally there are two heart sounds, and additional sounds indicate disease. If a third heart sound is present it could be a sign of heart failure whereas a murmur indicates defective valves or an orifice in the septal wall. The primary aim of this [...]
Possibilities for the development of a decision support system for diagnosing heart failure
Heart failure is a common disease which is difficult to diagnose. To aid physicians in diagnosing heart failure, a decision support system has been proposed. Parameters useful to the system are suggested. Some of these, such as age and gender, should be provided by the physician, and some should be derived from electro- and phonocardiographic [...]
Cardiovascular response to hyperoxemia, hemodilution and burns: a clinical and experimental study
The last decades less invasive monitoring and analytical tools have been developed for the evaluation of myocardial mechanics in clinical praxis. In critical care, these are longed-for complements to pulmonary artery catheter monitoring, additionally offering previously inaccessible information. This work is aimed, during fluid-replacement and oxygen therapy, to determine the physiological interface of ventricular and [...]
Evaluation and implementation of neural brain activity detection methods for fMRI
The brain is the most fascinating and least understood organ in the human body. For scientists and philosophers have tried to find the relationship between behaviour, emotion, memory, thought, consciousness and the physical body. In recent years,techniques for non-invasive monitoring of the working brain have experienced a strong development. Neuroimaging tools and methods have been [...]
CT-based measurement of lung volume and attenuation of deceased
Because of the difficulties in concluding whether a person has drowned or not, information that could be relevant for postmortal diagnosis of drowning was studied. With postmortal CT images lung volume, mean attenuation, anterior-posterior difference, lung density profile and amount of water within the lungs were investigated.The report also evaluates three examples of software that [...]
Aligning and Merging Biomedical Ontologies
Due to the explosion of the amount of biomedical data, knowledge and tools that are often publicly available over the Web, a number of difficulties are experienced by biomedical researchers. For instance, it is difficult to find, retrieve and integrate information that is relevant to their research tasks. Ontologies and the vision of a Semantic [...]
Aligning Biomedical Ontologies
The amount of biomedical information that is disseminated over the Web increases every day. This rich resource is used to find solutions to challenges across the life sciences. The Semantic Web for life sciences shows promise for effectively and efficiently locating, integrating, querying and inferring related information that is needed in daily biomedical research. One [...]